Reviewing the work on the botany and chemistry of marijuana which has appeared in the twelve years since the publication of the first edition of this work is both gratifying and dismaying. It is gratifying in that the conclusions reached earlier are in need of no significant re vision and dismaying in that they have been largely ignored. It is amazing that so little work has been done on such a fundamental issue as the effect of cannabidiol on the high and other actions of THC and that when studies on the high finally appeared they were done by Brazilians! Probably the red tape involved in doing research on humans with psychedelics is a major barrier. I am reminded of the failure of nearly thirty years of research to determine the influence of iso-LSD on the LSD experience. Likewise, only a few of the hundreds of THC and LSD homologs and analogs have been adequately tested for psychoactivity. Only a trickle of work has appeared on the promising marijuana clones.
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